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Cholecystokinin: A multi-functional molecular switch of neuronal circuits

✍ Scribed by Soo Yeun Lee; Ivan Soltesz

Publisher
Wiley (John Wiley & Sons)
Year
2010
Tongue
English
Weight
257 KB
Volume
71
Category
Article
ISSN
1932-8451

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✦ Synopsis

Abstract

Cholecystokinin (CCK), a peptide originally discovered in the gastrointestinal tract, is one of the most abundant and widely distributed neuropeptides in the brain. In spite of its abundance, recent data indicate that CCK modulates intrinsic neuronal excitability and synaptic transmission in a surprisingly cell‐type specific manner, acting as a key molecular switch to regulate the functional output of neuronal circuits. The central importance of CCK in neuronal networks is also reflected in its involvement in a variety of neuropsychiatric andneurological disorders including panic attacks and epilepsy. © 2010 Wiley Periodicals, Inc. Develop Neurobiol 71: 83–91, 2011

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