Cholecystectomy and colorectal cancer: Evidence from a cohort study on diet and cancer

✍ Scribed by R. Alexandra Goldbohm; Piet A. van den Brandt; Pieter van't Veer; Elisabeth Dorant; Ferd Sturmans; Rudolph J. J. Hermus

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: French
• Weight: 575 KB
• Volume: 53
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910530505

✦ Synopsis

The association between cholecystectomy and subsequent risk for colorectal carcinoma was investigated in a prospective cohort study on diet and cancer (n = 120,852), which is being conducted in the Netherlands from 1986 onwards among 120,852 men and women, aged 55 to 69. After a follow-up period of 3.3 years, 478 incident cases of colorectal cancer (258 men and 220 women) were identified in the cohort, 64 of whom reported at baseline to have undergone previous gall-bladder surgery (2 I men and 43 women). After adjustment for age and familial history of large-bowel cancer, the relative rate (RR) for colorectal cancer in subjects who had undergone cholecystectomy compared with those who had not was 1.81 in men (p = 0.02) and 1.47 in women (p = 0.05). Additional adjustment for parity, Quetelet index, alcohol intake and other dietary variables resulted in a RR of I .78 in men and I .5 I in women. In women, the highest RR was detected in the right colon (RR = 1.89), whereas in men, no site within the large bowel accounted specifically for the increased relative rate. In both men and women, the rate appeared to increase from approximately 6 years after cholecystectomy onward.