## Abstract ## Objective Increased osteoclast activity is a key factor in bone loss in rheumatoid arthritis (RA). This suggests that osteoclast‐targeted therapies could effectively prevent skeletal damage in patients with RA. Zoledronic acid (ZA) is one of the most potent agents for blocking osteo
Chlorpromazine protection against interleukin-1 and tumor necrosis factor-mediated activities in vivo
✍ Scribed by Riccardo Bertini; Manuela Mengozzi; Marina Bianchi; Jean D. Sipe; Pietro Ghezzi
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 437 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0192-0561
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The proinflammatory cytokines interleukin-1 and tumor necrosis factor-alpha are thought to play important roles in the pathophysiology of liver disease. Specific antagonists of these cytokines have been found in recent years. Interleukin-1 receptor antagonist is a specific interleukin-1 antagonist.
## Abstract Oral treatment of zinc modulates cytokine secretion during the gestation, lactation, and weaning periods. We used a experimental mice model of zinc supplementation during the perinatal stages to study the effects of this ion over the production of interleukin IL‐1α, IL‐12, and tumor nec