๐”– Bobbio Scriptorium
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Chlorpromazine and avoidance: A genetic analysis

โœ Scribed by C. Castellano; B. E. Eleftheriou; D. W. Bailey; A. Oliverio

Book ID
104769125
Publisher
Springer
Year
1974
Tongue
English
Weight
443 KB
Volume
34
Category
Article
ISSN
0033-3158

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โœฆ Synopsis

Chlorpromazine exerts a significantly higher impairment on the performance of C57BL/6By than on BALB/cBy inbred mice pretrained in an active avoidance task. The effects of the drug on this measure assessed in these two strains, their reciprocal F 1 hybrids, their recombinant inbred strains, and two C57BL/6By eongenic lines indicate that at least two genes modulate the action of chlorpromazine on avoidance behavior. It was possible to characterize one of the loci modulating the effect of chlorpromazine on avoidance performance. We assign the symbol Cpz. The locus is in chromosome 9, Linkage Group II.

๐Ÿ“œ SIMILAR VOLUMES

An analysis of chlorpromazine-induced su
An analysis of chlorpromazine-induced suppression of the avoidance response
โœ Donald Posluns ๐Ÿ“‚ Article ๐Ÿ“… 1962 ๐Ÿ› Springer ๐ŸŒ English โš– 807 KB

Chlorpromazine, one of the phenothiazine derivatives, suppresses the avoidance response at doses which neither produce ataxia nor impair the performance of an escape response (Cook et al. ; MILLn~ et M., 1957 a; MAF~II). The avoidance response suppression is a property of most, if not all, phenothia

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In mice, marked decrement in response strength occurred when conditioned avoidance responses were acquired under amphetamine but emitted without amphetamine or under chlorpromazine; or acquired under chlorpromazine and emitted without chlorpromazine or under amphetamine.