Chlorpromazine and amphetamine effects on three operant and on four discrete trial reinforcement schedules

✍ Scribed by Oakley S. Ray; Lyle W. Bivens

• Book ID: 104758368
• Publisher: Springer
• Year: 1966
• Tongue: English
• Weight: 687 KB
• Volume: 10
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00401897

✦ Synopsis

Several doses of chlorpromazine (CPZ) and amphetamine (AM_P) were given to rats trained on one of three operant schedules of reinforcement (VI 60 '~, FI 60", or FR 100) or one of three discrete trial schedules (conditioned approach, CA; conditioned discrimination, CD; or stimulus self selection, SSS). The discrete trial procedures were more resistant to disruption by CPZ than were the operant schedules. AMP facilitated behavior only in the VI and FI schedules and had differential effects in the CD schedule (milk reward showed much greater resistance to disruption than water rewarded behavior). AMP was also given to Ss trained to respond on one of three response levers for milk, water or food reinforcement. Food responding was most disrupted while milk responding was least disrupted. It is concluded that depressants--like CPZ--can be studied equally well in many behavioral procedures while compounds which activate--like amphetamine--require a variety of behavioral procedures to show their many different effects.