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Chloroquine-resistance molecular markers (Pfcrt T76 and Pfmdr-1 Y86) and amodiaquine resistance in Burkina Faso

✍ Scribed by Halidou Tinto; Lougué Guekoun; Issaka Zongo; Robert Tinga Guiguemdé; Umberto D’Alessandro; Jean Bosco Ouédraogo

Book ID
110870273
Publisher
John Wiley and Sons
Year
2008
Tongue
French
Weight
48 KB
Volume
13
Category
Article
ISSN
1360-2276

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Relationship between the Pfcrt T76 and the Pfmdr-1 Y86 mutations in Plasmodium falciparum and in vitro/in vivo chloroquine resistance in Burkina Faso, West Africa
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The relationship between Pfcrt T76 and Pfmdr-1 Y86 mutations in Plasmodium falciparum was explored in samples from patients with uncomplicated malaria and tested in vitro and in vivo with chloroquine (CQ) in Burkina Faso. The two mutations were strongly related. The Pfcrt T76 mutation was found in 8

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The choice of partner drug is critical for artemisinine-based combination therapy (ACT) to remain effective and amodiaquine (AQ) is one important candidate to evaluate. We treated 81 children <5 years with uncomplicated Plasmodium falciparum malaria with AQ alone and related the treatment outcome t