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Chloroquine allows the secretion of internalized 125I-epidermal growth factor from fibroblasts

✍ Scribed by E. Wakshull; Janet L. Cooper; Walker Wharton

Book ID
102880491
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
788 KB
Volume
125
Category
Article
ISSN
0021-9541

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Characterization of the rebinding of 125
Characterization of the rebinding of 125I-epidermal growth factor released from BALB/c-3T3 cells following accumulation in the presence of chloroquine
✍ Janet L. Cooper; Eric Wakshull; Walker Wharton πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 846 KB

Lysosomotropic amines, such as chloroquine and methylamine, increase the intracellular accumulation of 125I-EGF by inhibiting lysosomal degradation. It has been shown previously that BALB/c-3T3 cells, prelabeled at 4 degrees C with 125I-EGF for 3 h and subsequently chased at 37 degrees C in the pres