Role of lysosomes in hepatic accumulatio
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Anna C. Macintrye; David J. Cutler
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Article
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1988
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John Wiley and Sons
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English
β 455 KB
At therapeutic free concentrations (120-360 nM in rheumatoid arthritis), the accumulation ratio for chloroquine (7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-quinoline; CQ) in viable isolated rat hepatocytes is 795 +/- 33, which is of the same order of magnitude as in vivo hepatic uptake in th