𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chlorophyllin-enhanced excretion of urinary and fecal mutagens in rats given 2-amino-3-methylimidazo[4, 5-f]quinoline

✍ Scribed by Roderick Dashwood; Christina Liew

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
591 KB
Volume
20
Category
Article
ISSN
0893-6692

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Quantitation of 2-amino-3-methylimidazo[
Quantitation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline DNA adducts in specific sequences using alkali or uvrABC excinuclease
✍ Kazuhiro Nouso; Vilhelm A. Bohr; Herman A. J. Schut; Elizabeth G. Snyderwine 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 909 KB

## Abstract 2‐Amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ) and 2‐amino‐3,8‐dimethylimidazo[4,5‐__f__]quinoxaline (MelQx) are carcinogens found in cooked meats that form DNA adducts upon metabolic activation. Purified DNA from Chinese hamster ovary (CHO) cells was reacted in vitro with the active

Inhibition of DNA adduct formation of 2-
Inhibition of DNA adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3-methylimidazo[4,5-f]quinoline by dietary indole-3-carbinol in female rats
✍ Ying-Hui He; Herman A.J. Schut 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 171 KB 👁 1 views

2-Amino-1-methyl-6-phenylimidazo[4,5b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5f]quinoline (IQ) are two important heterocyclic amines formed in proteinaceous foods during the cooking process. Both PhIP and IQ are carcinogenic in several strains of rats. PhIP induces mammary tumors in female F3

Mutational analysis of Ctnnb1 and Apc in
Mutational analysis of Ctnnb1 and Apc in tumors from rats given 1,2-dimethylhydrazine or 2-amino-3-methylimidazo[4,5-f]quinoline: Mutational ‘hotspots’ and the relative expression of β-catenin and c-jun
✍ Carmen A. Blum; Tomoko Tanaka; Xiaoying Zhong; Qingjie Li; Wan-Mohaiza Dashwood; 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 243 KB

## Abstract There is growing interest in β‐catenin and its role in various human cancers. We recently reported that 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ)‐ and 1,2‐dimethylhydrazine (DMH)‐induced colon tumors in the rat contain mutations in __Ctnnb1__, the gene for β‐catenin, but the muta

In vivo mutational analysis of liver DNA
In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate
✍ Keita Kanki; Akiyoshi Nishikawa; Ken-ichi Masumura; Takashi Umemura; Takayoshi I 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB 👁 1 views

## Abstract In order to cast light on carcinogen‐specific molecular mechanisms underlying experimental hepatocarcinogenesis in rats, in vivo mutagenicity and mutation spectra of known genotoxic rat hepatocarcinogens __N__‐nitrosopyrrolidine (NPYR), and 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (I

Inhibition of plasmid reporter gene expr
Inhibition of plasmid reporter gene expression in cho cells by DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5–b]pyridine
✍ Liju Fan; Elizabeth G. Snyderwine 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 667 KB

## Abstract 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline (IQ) and 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐__b__)]pyridine (PhIP) are two members of a family of carcinogenic heterocyclic amines (HAs) found in cooked meats that form DNA adducts after activation to __N__‐acetoxy derivatives. The ability of IQ

Enhancing effects of simultaneous treatm
Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine
✍ Yasuki Kitamura; Takashi Umemura; Kazushi Okazaki; Keita Kanki; Takayoshi Imazaw 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 150 KB

## Abstract Combined effects of sodium nitrite (NaNO~2~) and 2‐amino‐3‐methylimidazo[4,5‐__f__]quinoline (IQ) on liver, colon and Zymbal's gland carcinogenesis were assessed using a rat two‐stage carcinogenesis model, with a focus on involvement of oxidative stress. Male 6‐week‐old F344 rats were g