Chitosan-Modified Dry Powder Formulations for Pulmonary Gene Delivery
β Scribed by Hao-Ying Li; James Birchall
- Publisher
- Springer US
- Year
- 2006
- Tongue
- English
- Weight
- 732 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0724-8741
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Chitosan-plasmid DNA (pDNA) complex powders as a pulmonary gene delivery system were prepared with a supercritical carbon dioxide (CO(2)) process and their in vivo activity was evaluated. The powders with mannitol as a carrier were prepared by dispersing aqueous solutions of a luciferase expression
## Abstract ## Background Dry powder dispersion devices offer potential for delivering therapeutic macromolecules to the pulmonary epithelia. Previously, freezeβdrying (lyophilisation) has been the accepted method for preparing dried formulations of proteins and nonβviral gene vectors despite the