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Chitosan-Modified Dry Powder Formulations for Pulmonary Gene Delivery

✍ Scribed by Hao-Ying Li; James Birchall


Publisher
Springer US
Year
2006
Tongue
English
Weight
732 KB
Volume
23
Category
Article
ISSN
0724-8741

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Chitosan-plasmid DNA (pDNA) complex powders as a pulmonary gene delivery system were prepared with a supercritical carbon dioxide (CO(2)) process and their in vivo activity was evaluated. The powders with mannitol as a carrier were prepared by dispersing aqueous solutions of a luciferase expression

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## Abstract ## Background Dry powder dispersion devices offer potential for delivering therapeutic macromolecules to the pulmonary epithelia. Previously, freeze‐drying (lyophilisation) has been the accepted method for preparing dried formulations of proteins and non‐viral gene vectors despite the