Chitosan-Indomethacin Conjugates. Effect of Different Substituents on the Polysaccharide Molecule on Drug Release
✍ Scribed by Isabella Orienti; Khaled Aiedeh; Elisabetta Gianasi; Cristina Ponti; Vittorio Zecchi
- Book ID
- 102750423
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 528 KB
- Volume
- 329
- Category
- Article
- ISSN
- 0365-6233
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Chitosan diacetate (CDA) was prepared by alkylating the amino moieties of chitosan with mono-iodoacetic acid. Subsequently, CDA was cross-linked with Al 3þ , Zn 2þ , and Ca 2þ ions to yield three ionotropically crosslinked polymeric matrices. These composite matrices were characterized employing inf
## Abstract An ionically crosslinked polymer network composed of chitosan and sodium hexametaphosphate (SHMP) was synthesized to determine their swelling and ascorbic acid release kinetics at various SHMP concentrations. The chitosan/SHMP hydrogels were synthesized using an acetic acid aqueous solu