Chiroptical properties of unsaturated peptides

✍ Scribed by Osvaldo Pieroni; Adriano Fissi; Giorgio Montagnoli

• Publisher: Wiley (John Wiley & Sons)
• Year: 1973
• Tongue: English
• Weight: 165 KB
• Volume: 12
• Category: Article
• ISSN: 0006-3525
• DOI: 10.1002/bip.1973.360120619

✦ Synopsis

It is known that rigid short range structures such as certain model amides' and diketopiperazinesz can produce ORD and CD spectra with Cotton effects somewhat similar to those displayed by stereo-ordered macromolecules. In this connection, unsaturated peptides,3 in which the rigidity of the chain is enhanced by the carbon-carbon double bond, can be of particular interest.

In the present preliminary communication some features are reported concerning absorption, ORD, and CD spectra in the near U.V. of six N-acylated unsaturated peptides containing one (I) or two (11) dehydrophenylalanyl residues and having respectively C-terminal Lalanine (A), bphenylalanine (Ph), and L-glutamic acid (G) residues.