Chirality transfer from silicon to carbon: use of optically pure cyclic silanes with a binaphthalene chiral unit

✍ Scribed by Michael E. Jung; Keith T. Hogan

• Book ID: 104217746
• Publisher: Elsevier Science
• Year: 1988
• Tongue: French
• Weight: 309 KB
• Volume: 29
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)82304-7

✦ Synopsis

The optically pure binaphthylic cyclic silanes R-6 and S-6 have been prepared and used in reductions and aldol condensations to achieve some of the highest ee's yet reported for chirality transfer with organosilanes.

A major goal in synthetic organic chemistry today is the easy and efficient production of optically active materials from prochiral precursors by asymmetric induction. 2 Great advances have been made recently in this arca in a wide variety of reaction types: epoxidation,3a oxidation,3h-e reduction,3e-h 1,4-addition ,je alkylation,3uk aldol condensation,3il