Chirality in Drug Design and Synthesis

✍ Scribed by C. Brown (Eds.)

• Publisher: Academic Press
• Year: 1990
• Tongue: English
• Leaves: 252
• Category: Library

✦ Synopsis

This is a text which deals with the property of left-handed and right-handed structural form in chemicals used in drug design and drug synthesis. The book covers pharmacological, medical, organic chemical and toxicological applications

✦ Table of Contents

Content:
Dedication, Page ii
Front Matter, Page iii
Copyright, Page iv
Contributors, Pages v-vi
Foreword, Pages vii-viii, C.W. REES
Introduction, Pages xiii-xv
1 - Chirality: Pharmacological Action and Drug Development, Pages 1-28, MARTHA HYNECK, JOHN DENT, JERRY B. HOOK
2 - Racemic Therapeutics—Problems all Along the Line, Pages 29-43, E.J. ARIENS
3 - Chirality, Drug Metabolism and Action, Pages 45-51, DONALD S. DAVIES
4 - From Enzyme Mimics to Molecular Self-Assembly Processes, Pages 53-81, J. FRASER STODDART
5 - Modelling of Drug-Receptor Interactions: Stereoselectivity of 5-Hydroxytryptamine and Dopamine Receptors in the Brain, Pages 83-84,p1-p4,85-100, ULI HACKSELL, ANETTE M. JOHANSSON, ANDERS KARLÉN, KRISTINA LUTHMAN, CHARLOTTA MELLIN
6 - Molecular Basis of the Activity of Antibiotics of the Vancomycin Group: Guides for Peptide–Peptide Binding, Pages 101-113, DUDLEY H. WILLIAMS, ANDREW J. DOIG, JONATHAN P.L. COX, IAN A. NICHOLLS, MARK GARDNER
7 - Recent Developments in the Use of Enzyme-Catalysed Reactions in Organic Synthesis, Pages 115-130, STANLEY M. ROBERTS
8 - Recent Progress in Research on the Immunosuppressant FK-506, Pages 131-165, PHILIP KOCIENSKI, MICHAEL STOCKS, DAVID K. DONALD
9 - A Practical, Enantioselective Synthesis of [R-(R, S)]-β-[(2-Carboxyethyl)thio]-α-hydroxy-2-(8-phenyloctyl)-benzenepropanoic Acid (SK&F 104353), a Potent LTD₄ Antagonist, Pages 167-180, IVAN LANTOS, VANCE NOVACK
10 - Chirality Recognition in Synthesis, Pages 181-198, STEPHEN G. DAVIES
11 - Sultam-directed asymmetric syntheses of α-amino acids, Pages 199-214, WOLFGANG OPPOLZER
Appendix: Abstracts of Posters, Pages 215-236
Index, Pages 237-243