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Chiral Thiourea-Phosphine Organocatalysts in the Asymmetric Aza-Morita–Baylis–Hillman Reaction

✍ Scribed by Yong-Ling Shi; Min Shi

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
153 KB
Volume
349
Category
Article
ISSN
1615-4150

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✦ Synopsis

Abstract

A new kind of bifunctional (thio)urea‐phosphine catalyst was synthesized and applied to the aza‐Morita–Baylis–Hillman reaction of N‐sulfonated imines with methyl vinyl ketone, phenyl vinyl ketone, ethyl vinyl ketone or acrolein. Moderate to excellent ee and yields of the products were obtained under mild reaction conditions.

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Dendritic Chiral Phosphine Lewis Bases-C
Dendritic Chiral Phosphine Lewis Bases-Catalyzed Asymmetric Aza-Morita–Baylis–Hillman Reaction of N-Sulfonated Imines with Activated Olefins
✍ Ying-hao Liu; Min Shi 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 242 KB 👁 2 views

## Abstract A series of polyether dendritic chiral phosphine Lewis bases was synthesized, and successfully applied to the asymmetric aza‐Morita–Baylis–Hillman reaction of __N__‐sulfonated imines (__N__‐arylmethylidene‐4‐methylbenzenesulfonamides) with methyl vinyl ketone (MVK), ethyl vinyl ketone (