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Chiral synthesis via organoboranes. 41. The utility of B-chlorodiisopinocampheylborane for a general synthesis of enantiomerically pure drugs

✍ Scribed by P. Veeraraghavan Ramachandran; Baoqing Gong; Herbert C. Brown


Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
774 KB
Volume
7
Category
Article
ISSN
0899-0042

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Synthesis of the title compounds is described, starting from alkylation of the pyroglutaminol-acetal 4a"' at the a-lactam position C-6 with methyl iodide. Subsequent addition of 2-cyclohexen-lone led to diastereoselective formation of the 1.2-aldol addition product 7 W c , which after dehydratizatio