✦ LIBER ✦
Chiral synthesis via organoboranes. 25. B-(Z and E)-crotylbis-(2-isocaranyl)boranes as valuable reagents for the asymmetric crotylboration of aldehydes
✍ Scribed by Herbert C. Brown; Ramnarayan S. Randad
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 351 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0040-4020
No coin nor oath required. For personal study only.
✦ Synopsis
The asymmetric crotylboration of representative aldehydes, RCHO (R = Me, Et-), with B-[Z and El-crotylbis@isocaranyl)boranes (4 and 5) proceeds with remarkably high enantioselectivity (>94-98% ee) and diastereoselectivity (>99% de) at -78 Oc in ethyl ether.