Chiral stationary phases and circular dichroism detection in high-performance liquid chromatography: Determination of stereochemical purity of drugs
โ Scribed by Carlo Bertucci; Carlo Rosini; Dario Pini; Piero Salvadori
- Book ID
- 103910848
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 256 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0731-7085
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๐ SIMILAR VOLUMES
The application of a circular dichroism (c.d.) detection system in HPLC using a chiral stationary phase is presented. The simultaneous measurement of the absorbance and c.d. signal allows the evaluation of the anisotropy factor (g = delta epsilon/epsilon) and thus the determination of the enantiomer
A high-performance liquid chromatographic method has been developed for the analysis of the intermediate imines and end products in an asymmetric isomerization route toward optically active amines. Separation of the imine enantiomers was performed on commercially available Chiralcel OD-H, Chiralcel