Thoroughly revised, with either entirely new or completely updated contents, this is a practical manual for the small and large-scale preparation of enantiomerically pure products. The result is a vital resource for meeting the highest purity standards in the manufacture of chiral pharmaceuticals, food additives and related compounds. All the approaches covered here are highly relevant to modern manufacturing and quality control schemes in the pharmaceutical and biotech industries, addressing the increasingly important issue of drug safety in view of tougher regulatory standards worldwide.Content:
Chapter 1 Method Development and Optimization of Enantioseparations Using Macrocyclic Glycopeptide Chiral Stationary Phases (pages 1โ28): Thomas E. Beesley and J. T. Lee
Chapter 2 Role of Polysaccharides in Chiral Separations by Liquid Chromatography and Capillary Electrophoresis (pages 29โ97): Imran Ali and Hassan Y. Aboul?Enein
Chapter 3 Analytical and Preparative Potential of Immobilized Polysaccharide?Derived Chiral Stationary Phases (pages 99โ134): Tong Zhang and Pilar Franco
Chapter 4 Chiral Separations Using Supercritical Fluid Chromatography (pages 135โ154): Karen W. Phinney and Rodger W. Stringham
Chapter 5 Chiral Separation by Ligand Exchange (pages 155โ179): Gerald Gubitz and Martin G. Schmid
Chapter 6 Advances in Simulated Moving Bed Chromatographic Separations (pages 181โ202): Pedro Sa Gomes, Mirjana Minceva, Luis S. Pais and Alirio E. Rodrigues
Chapter 7 Less Common Applications of Enantioselective HPLC Using the SMB Technology in the Pharmaceutical Industry (pages 203โ273): Stefanie Abel and Markus Juza
Chapter 8 Enantiomer Separation by Chiral Crown Ether Stationary Phases (pages 275โ299): Myung Ho Hyun
Chapter 9 Enantioselective Separation of Amino Acids and Hydroxy Acids by Ligand Exchange with Copper(II) Complexes in HPLC (Chiral Eluent) and in Fast Sensing Systems (pages 301โ331): Rosangela Marchelli, Roberto Corradini, Gianni Galaverna, Arnaldo Dossena, Francesco Dallavalle and Stefano Sforza
Chapter 10 Enantiomer Separation by Capillary Electrophoresis (pages 333โ368): Gerhard K. E. Scriba
Chapter 11 Counter?Current Chromatography in the Separation of Enantiomers (pages 369โ397): Eva Perez and Cristina Minguillon
Chapter 12 Separation of Enantiomers Using Molecularly Imprinted Polymers (pages 399โ431): Borje Sellergren
Chapter 13 Enantioselective Biosensors (pages 433โ439): Raluca?Ioana Stefan?van Staden, Jacobus Frederick van Staden and Hassan Y. Aboul?Enein
Chapter 14 Chiral Analysis in Capillary Electrochromatography (CEC) and CEC Coupled to Mass Spectrometry (pages 441โ504): Jie Zheng and Shahab A. Shamsi
Chapter 15 Chiral Analysis Using Polymeric Surfactants in Micellar Electrokinetic Chromatography (MEKC) and MEKC Coupled to Mass Spectrometry (pages 505โ560): Syed A. A. Rizvi and Shahab A. Shamsi
Chapter 16 Polarimeter Chiral Detectors in Enantioseparations (pages 561โ584): Gary W. Yanik
Chapter 17 Preparative Chiral Chromatography โ a Powerful and Efficient Tool in Drug Discovery (pages 585โ600): Shalini Andersson