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Chiral separation of some non-steroidal anti-inflammatory drugs on tartardiamide DMB chiral stationary phase by HPLC

✍ Scribed by Hassan Y. Aboul-Enein

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 156 KB
Volume: 26
Category: Article
ISSN: 1615-9306
DOI: 10.1002/jssc.200390070

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✦ Synopsis

Abstract

Selected non‐steroidal anti‐inflammatory drugs (NSAIDs), namely racemic flurbiprofen, ibuprofen, fenprofen, tiaprofenic acid, ketoprofen, and tolmetin were resolved on Kromasil tartardiamide‐DMB chiral stationary phase. Optimum resolution was achieved using a mobile phase consisting of hexane: tert‐butyl methyl ether:acetic acid (75 : 25 : 0.1 v/v/v) at flow rate of 1 mL/min. The capacity (k), separation (α), and resolution factors (Rs) are reported. The mechanisms of chiral recognition between the analytes and the chiral selector are discussed.

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✍ Hassan Y. Aboul-Enein; Laila I. Abou-Basha; Soliman A. Bakr 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 374 KB 👁 2 views

The enantiomeric separation of several racemic aryloxyaminopropan-2-01 derivatives related to propranolol on normal and reversed phase of cellulose tris (3,5-dimethylphenyl carbamate) chiral stationary phases known as Chiralcel OD and Chiralcel OD-R were studied. It was observed that the chiral sepa