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Chiral separation of ibuprofen and chiral pharmacokinetics in healthy chinese volunteers

✍ Scribed by Chaonan Zheng; Haiping Hao; Guangji Wang; Guowei Sang; Jianguo Sun; Peng Li; Jing Li

Publisher
Springer-Verlag
Year
2008
Tongue
English
Weight
761 KB
Volume
33
Category
Article
ISSN
0378-7966

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Pharmacokinetics of ibuprofen enantiomer
Pharmacokinetics of ibuprofen enantiomers in plasma and suction blister fluid in healthy volunteers
✍ Judith S. Walker; Romualda D. Knihinicki; Peter Seideman; Richard O. Day πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 514 KB

After a single oral dose of (R,S)-ibuprofen (1200 mg) to five healthy volunteers, paired plasma and blister fluid concentrations of drug were determined by a stereospecific HPLC assay. A pharmacokinetic model that incorporated blister fluid as a separate peripheral compartment adequately characteriz