Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has received considerable attention as a potential anticancer agent. However, recombinant Apo2L/TRAIL has several limitations, which include a weak pharmacokinetic profile, namely, a short biological half-life and rapid renal clearance,
✦ LIBER ✦
Chiral ruthenium complexes induce apoptosis of tumor cell and interact with bovine serum albumin
✍ Scribed by Fang Yuan; Xiaojia Chen; Yanan Liu; Tingting Zhang; Dongdong Sun; Jie Liu
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 397 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0899-0042
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## BACKGROUND. The mechanism behind castration-induced apoptosis in prostate cells is unknown, but data from other species suggest that transforming growth factor 1 (TGF-1) may be involved. METHODS. By using quantitative RT-PCR and immunohistochemistry, expression of TGF-1 and its receptors typ