Chiral resolution of flobufen by high performance liquid chromatography and capillary electrophoresis

✍ Scribed by Eva Tesarvá; Martin Gila; Alexandr Jegorov; M. Uhrová; Zdenck Deyl

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 119 KB
• Volume: 11
• Category: Article
• ISSN: 0269-3879
• DOI: 10.1002/(sici)1099-0801(199709)11:5<321::aid-bmc710>3.0.co;2-j

✦ Synopsis

The enantiomeric separation of an anti-inflammatory drug flobufen was performed on various chiral columns in liquid chromatography and by reversed phase chromatography and by capillary electrophoresis with ␤cyclodextrin as a chiral selector in the mobile phase and background electrolyte, respectively. The elution order of individual enantiomers is discussed with respect to the absolute chirality of ( ± )-flobufen determined by X-ray crystallography.