Chiral resolution of clenbuterol, cimaterol, and mabuterol on Chirobiotic V, T, and TAG columns

✍ Scribed by Hassan Y. Aboul-Enein; Imran Ali

• Book ID: 101394839
• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 178 KB
• Volume: 25
• Category: Article
• ISSN: 1615-9306
• DOI: 10.1002/1615-9314(20020901)25:13<851::aid-jssc851>3.0.co;2-m

✦ Synopsis

Chiral resolution of clenbuterol, cimaterol, and mabuterol on Chirobiotic V, T, and TAG columns

The enantiomeric resolution of adrenergic b 2 -agonists (clenbuterol, cimaterol, and mabuterol) on different Chirobiotic columns (Chirobiotic V, T, and TAG) has been achieved with methanol-acetonitrile-triethylamine (80 : 20 : 0.05, v/v/v) as mobile phase. The a values of the resolved enantiomers of clenbuterol, cimaterol, and mabuterol were 1.10 to 4.26 while the values of R s varied from 1.0 to 2.10. The resolution was in the order of Chirobiotic V A Chirobiotic TAG A Chirobiotic T whereas the enantioselectivity was in the order of Chirobiotic TAG A Chirobiotic V A Chirobiotic T. The enantiomeric resolution of adrenergic b 2 -agonists on Chirobiotic columns is governed by a complex mechanism involving various types of steric interactions.