Chiral Recognition of Phenylacetic Acid Derivatives by Aminated Cyclodextrins
✍ Scribed by Takashi Kitae; Hiroshi Takashima; Koji Kano
- Book ID
- 110258433
- Publisher
- Springer Netherlands
- Year
- 1999
- Tongue
- English
- Weight
- 177 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0923-0750
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## Abstract Chiral recognition by cyclodextrins is of considerable importance, especially for pharmaceutical industry, in view of the possible side effects of the second enantiometer of chiral drugs. In general, it manifests itself in all NMR parameters (chemical shifts, coupling constants, NOE and
## Abstract The two pyrrolidinylidenesulfamido‐modified __β__‐cyclodextrins (__β__‐CDs) **3** and **4** were prepared and studied for chiral discrimination of the enantiomers (__R__)‐ and (__S__)‐**1** of zolmitriptan. The pyrrolidinylidenesulfamido spacer improved the chiral discrimination and bin