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Chiral quantification of D-, L-phenylglycine mixture using mass spectrometric kinetic method

✍ Scribed by Li Ming; Liu Zhiqiang; Chen Huanwen; Liu Shuying; Jin Qinhan

Book ID
102380614
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
96 KB
Volume
40
Category
Article
ISSN
1076-5174

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✦ Synopsis

Abstract

A novel mass spectrometric method is applied to rapid, accurate, quantitative analysis of chiral phenylglycine. Transition‐metal–bound complex ions containing the chiral phenylglycine are generated by electrospray ionization mass spectrometry and subjected to collision‐induced dissociation. The ratio of the two competitive dissociation rates is related to the enantiomeric composition of the mixture, allowing the determination of enantiomeric contamination in the intermediates. Copyright Β© 2005 John Wiley & Sons, Ltd.

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