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Chiral Pyridines: Optical Resolution of 1-(2-Pyridyl)- and 1-[6-(2,2‘-Bipyridyl)]ethanols by Lipase-Catalyzed Enantioselective Acetylation

✍ Scribed by Uenishi, Jun'ichi; Hiraoka, Takao; Hata, Shinichiro; Nishiwaki, Kenji; Yonemitsu, Osamu; Nakamura, Kaoru; Tsukube, Hiroshi

Book ID
120657789
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
91 KB
Volume
63
Category
Article
ISSN
0022-3263

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High enantioselectivity was achieved in the lipase-catalyzed kinetic resolution of 5-hydroxypyrrolidin-2one and 5-hydroxy-1,5-dihydropyrrol-2-one derivatives. Lipase PS and Novozym 435 were the successful catalysts (E=>1000). The acetylation of the N-protected 5-hydroxy-1,5-dihydropyrrol-2-one deriv