Chiral nuclear magnetic resonance shift reagents: Lanthanide mixtures with 1-(1-naphthyl) ethylurea derivatives of amino acids
✍ Scribed by Thomas J. Wenzel; Rebecca D. Miles; Sarah E. Weinstein
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 153 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0899-0042
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✦ Synopsis
A newly developed reversed phase cellulose tris(4-methyl benzoate) known as Chiralcel OJ-R was used to investigate the chiral recognition and enantiomeric separation of eight racemic piperidine-2,6-dione compounds-namely, aminoglutethimide and its major metabolite acetylaminoglutethimide, glutethimide, cyclohexylaminoglutethimide, pyridoglutethimide, thalidomide, phenglutarimide, and 3-phenylacetylamino-2,6-piperidinedione (antineoplaston A-10). Chiral separation of these compounds was achieved under varying ratios of the mobile phase, except for phenglutarimide and 3-phenylacetylamino-2,6-piperidinedione, for which separation was unsuccessful. Possible chiral recognition mechanisms are also presented. Chirality 9: 10-12, 1997.