Chiral Nanoscale Metal–Organic Tetrahedral Cages: Diastereoselective Self-Assembly and Enantioselective Separation

✍ Scribed by Taifeng Liu; Yan Liu; Weimin Xuan; Yong Cui

• Book ID: 102728535
• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 582 KB
• Volume: 49
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.201000416

✦ Synopsis

Crystallization separation experiment: Racemic 2-butanol (4 mL) or 3-methyl-2-butanol (4 mL) was added dropwise to a solution of the apohost 1 (40 mg) in dry CHCl 3 at room temperature. The resulting solutions were allowed to evaporate slowly; the inclusion solids formed after two days. The solid were filtered and washed with diethyl ether to remove surface solvent molecules. The guest alcohols were removed from the inclusion solids of 1•(guest) 3 by washing with MeOH. Elemental analysis calcd (%) for the adduct C 192 H 246 Fe 4 O 51 (1•(2-butanol) 3 ): C 64.18, H 6.90; found: C 64.28, H 6.87. Calcd (%) for the adduct C 195 H 252 Fe 4 O 51 ([Fe 4 L 6 ]•(3-methyl-2butanol) 3 ): C 64.42, H 6.99; found: C 64.32, H 6.90. Optical purity of the guests was determined by GC using a Chiral-G-TA capillary column (ASTEC Company; 30 m 0.25 mm internal diameter). Other experimental details are given in the Supporting Information.