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Chiral N-substituted glycines can form stable helical conformations

✍ Scribed by Philippe Armand; Kent Kirshenbaum; Alexis Falicov; Roland L Dunbrack Jr; Ken A Dill; Ronald N Zuckermann; Fred E Cohen


Book ID
114382649
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
625 KB
Volume
2
Category
Article
ISSN
1359-0278

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✍ Tracy J. Sanborn; Cindy W. Wu; Ronald N. Zuckermann; Annelise E. Barron 📂 Article 📅 2001 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 180 KB 👁 1 views

## Abstract Poly‐N‐substituted glycines or “peptoids” are protease‐stable peptide mimics. Although the peptoid backbone is achiral and lacks hydrogen‐bond donors, substitution with α‐chiral side chains can drive the formation of stable helices that give rise to intense CD spectra. To systematically