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Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of pioglitazone enantiomers in rats

โœ Scribed by Du, Bin; Pang, Li; Yang, Yanhua; Shen, Guopeng; Zhang, Zhenzhong

Book ID
121647651
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
745 KB
Volume
951-952
Category
Article
ISSN
1873-376X

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The chromatographic resolution of rac-doxazosin using reversed-phase high performance liquid chromatography (HPLC) with the chargeable chiral mobile phase additive, carboxymethyl-beta-cyclodextrin (CM-beta-CD), is described. The effects of different modifiers (acetonitrile, methanol and tetrahydrofu