Chiral Ionic Phosphites and Diamidophosphites: A Novel Group of Efficient Ligands for Asymmetric Catalysis

✍ Scribed by Konstantin N. Gavrilov; Sergey E. Lyubimov; Oleg G. Bondarev; Marina G. Maksimova; Sergey V. Zheglov; Pavel V. Petrovskii; Vadim A. Davankov; Manfred T. Reetz

• Publisher: John Wiley and Sons
• Year: 2007
• Tongue: English
• Weight: 120 KB
• Volume: 349
• Category: Article
• ISSN: 1615-4150
• DOI: 10.1002/adsc.200600372

✦ Synopsis

Abstract

Seven members of a new class of chiral P‐monodentate cationic phosphites and diamidophosphites have been synthesized for the first time and tested as ligands in asymmetric transition metal catalysis. Up to 96 % ee was achieved in the rhodium‐catalyzed asymmetric hydrogenation of functionalized olefins and up to 99 % ee in the palladium‐catalyzed allylic allylation. Applications of the immobilized cationic rhodium complex to asymmetric catalytic synthesis have also been demonstrated.