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Chiral formamidines. The mechanism of mono- and di-alkylation leading to chiral, non-racemic tetrahydroisoquinolines.

โœ Scribed by A.I. Meyers; Joseph S. Warmus; Michael A. Gonzalez; Joseph Guiles; Atsushi Akahane


Book ID
103406127
Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
225 KB
Volume
32
Category
Article
ISSN
0040-4039

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Chiral 3-alkyl-3-arylpyrrolidines were prepared from the substituted bicyclic lactams. Stereoselectivity in the alkylation of bicyclic lactams was improved by using an alkyl triflate or tosylate as the electrophile.