Chiral Diselenides in Asymmetric Cyclization Reactions

✍ Scribed by Gianfranco Fragale; Thomas Wirth

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 282 KB
• Volume: 1998
• Category: Article
• ISSN: 1434-193X
• DOI: 10.1002/(sici)1099-0690(199807)1998:7<1361::aid-ejoc1361>3.0.co;2-m

✦ Synopsis

The use of chiral selenium electrophile 6 generated in situ atoms can be generated selectively with diastereoselectivities up to 85% when geminal disubstituted alkenes from the chiral diselenide 5 in asymmetric ring closure reactions of unsaturated alcohols, carboxylic acids and are used. The cyclization of vinylic silanes leads to versatile building blocks for further synthetic transformations. carbamates is presented herein. Tetrasubstituted carbon