Chiral Diazaligands for Asymmetric Synthesis

✍ Scribed by Diego Savoia (auth.), Marc Lemaire, Pierre Mangeney (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2005
• Tongue: English
• Leaves: 311
• Series: Topics in Organometallic Chemistry 15
• Edition: 1
• Category: Library

✦ Synopsis

The use of phosphine derivatives has historically induced the tremendous development of catalysis (both non-asymmetric and asymmetric). Although the chemistry of amines is more documented, the use of nitrogen-containing ligands only appeared recently. Nevertheless, during the last ten years, the results describing chiral diamine preparations and their uses in asymmetric catalysis and synthesis are increasing faster than their phosphorus counterparts. The reader will find in this volume the most recent methods for the synthesis of chiral diamines as well as their applications in asymmetric catalysis of CC bond formation. Particular attention will be given to spartein and derivatives of such diamines. Recently, the particular properties and the chemistry of amines allowed to obtain catalysts easy to separate and recycle and new types of ligands such as diaminocarbenes, ureas and thioureas. Finally, the complexing properties of some diamines allowed the formation of complexes with chirality "at the metal " which is of major theoretical interest and presents numerous potential applications.

✦ Table of Contents

Progress in the Asymmetric Synthesis of 1,2-Diamines from Azomethine Compounds....Pages 1-58
Sparteine as a Chiral Ligand for Asymmetric Catalysis....Pages 59-92
Use of N , N -Coordinating Ligands in Catalytic Asymmetric C--C Bond Formations: Example of Cyclopropanation, Diels--Alder Reaction, Nucleophilic Allylic Substitution....Pages 93-148
Non-covalent Immobilization of Catalysts Based on Chiral Diazaligands....Pages 149-190
Chiral Diaminocarbene Complexes, Synthesis and Application in Asymmetric Catalysis....Pages 191-229
Chiral Ureas and Thiroureas in Asymmetric Catalysis....Pages 231-270
Chiral-at-Metal Complexes as Asymmetric Catalysts....Pages 271-288

✦ Subjects

Organometallic Chemistry; Medicinal Chemistry; Inorganic Chemistry; Catalysis