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Chiral Brønsted Acid-Catalyzed Enantioselective Multicomponent Mannich Reaction: Synthesis of anti -1,3-Diamines Using Enecarbamates as Nucleophiles

✍ Scribed by Dagousset, Guillaume; Drouet, Fleur; Masson, Géraldine; Zhu, Jieping


Book ID
120674433
Publisher
American Chemical Society
Year
2009
Tongue
English
Weight
313 KB
Volume
11
Category
Article
ISSN
1523-7060

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Synthesis of Chiral 1,3-Diamines Derived
✍ Dr. Koichi Kodama; Kazuyuki Sugawara; Prof. Takuji Hirose 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 438 KB 👁 1 views

## Abstract In this study, 13 different chiral 1,3‐diamines were synthesized from (−)‐__cis__‐2‐benzamidocyclohexanecarboxylic acid. They were successfully applied as ligands in the Cu‐catalyzed asymmetric Henry reaction between benzaldehyde and nitromethane. It was confirmed that the enantioselect