## Abstract The metabolism of the nonsteroidal antiinflammatory drug flobufen, 4โ(2โฒ,4โฒโdifluorobiphenylโ4โyl)โ2โmethylโ4โoxobutanoic acid, was studied in primary cultures of human hepatocytes prepared by twoโstep collagenase perfusion of livers from four donors. Racemic flobufen or its individual
โฆ LIBER โฆ
Chiral aspects of drug metabolism
โ Scribed by Bernard Testa
- Book ID
- 119111722
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 422 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0165-6147
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Ethosuximide is a chiral drug substance primarily indicated for the treatment of absence seizures. This drug is used clinically as the racemate. The urinary metabolites of ethosuximide (following i.p. administration of the racemate or individual enantiomers to rats) have been studied using chiral ga