Chiral amine-thioureas bearing multiple hydrogen bonding donors: highly efficient organocatalysts for asymmetric Michael addition of acetylacetone to nitroolefins
β Scribed by Wang, Chun-Jiang; Zhang, Zhi-Hai; Dong, Xiu-Qin; Wu, Xiao-Jun
- Book ID
- 117990031
- Publisher
- Royal Society of Chemistry
- Year
- 2008
- Tongue
- English
- Weight
- 560 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1359-7345
- DOI
- 10.1039/b718949d
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π SIMILAR VOLUMES
A new efficient catalyst system for the asymmetric addition of acetylacetone to nitroolefins using a chiral bifunctional organocatalyst bearing multiple hydrogen-bonding donors was developed. When using the organocatalyst 2c derived from natural cinchona alkaloid in optimal conditions, up to 98% che
## Abstract A highly diastereoselective and enantioselective Michael addition of cyclohexanone, acetone and other ketones to nitroolefins was developed by the use of an amine organocatalyst based on bispidine. Additionally, a theoretical study of transition structures revealed that this bispidineβb