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Chiral 1,3-cyclobutane amino acids: Syntheses and extended conformations

✍ Scribed by Kevin Burgess; Shiming Li; Joe Rebenspies

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
215 KB
Volume
38
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Optically active samples of the N-protected 1,3-cyclobutane amino acids 1 and 2 were prepared from ct-pinene. The synthesis of 1 is enantiodivergent insofar as both optical antipodes of the product can be prepared from the same a-pinene enantiomer. Single crystal X-ray diffraction studies of derivatives of 1 reveal these compounds can have extended conformations.

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