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Chiral 1,2,4-triazole derivatives as potential synthetic intermediates

✍ Scribed by Alan R. Katritzky; Jin Wang; Peter Leeming; Peter J. Steel


Book ID
103977521
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
556 KB
Volume
7
Category
Article
ISSN
0957-4166

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πŸ“œ SIMILAR VOLUMES


Asymmetric induction using chiral 1,2,4-
✍ Alan R. Katritzky; Diana C. Aslan; Peter Leeming; Peter J. Steel πŸ“‚ Article πŸ“… 1997 πŸ› Elsevier Science 🌐 English βš– 627 KB

Lithiated N-substituted 1,2,4-triazoles 3 and 8 and benzimidazole 11 reacted with (1R)-fenchone to give derivatives 5c, 9 and 12 in good yields as single diastereoisomers. (S)-Lactic acid 16 reacted with o-phenylenediamine 15 to give optically pure (53-2-(1-hydroxyethyl)benzimidazole 17 (85%). Ring