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CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

✍ Scribed by Qian, Shu-Bing; McDonough, Holly; Boellmann, Frank; Cyr, Douglas M.; Patterson, Cam


Book ID
109895704
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
430 KB
Volume
440
Category
Article
ISSN
0028-0836

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## Abstract The Myc oncoprotein serves a dual function by stimulating cells both towards growth and apoptosis. The latter functions are often abrogated during tumor development. The Hsp70 stress protein is a potent anti‐apoptotic molecule, but its potential role in protecting cells from Myc‐mediate