Chingazumianine, a Novel Dichlorinated Alkaloid from Corydalis koidzumiana

✍ Scribed by Sheng-Ching Chan; Mei-Ing Chung; Ming-Hong Yen; Guan-Huei Lien; Chun-Nan Lin; Michael Y. Chiang

• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: German
• Weight: 103 KB
• Volume: 83
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/1522-2675(20001108)83:11<2993::aid-hlca2993>3.0.co;2-a

✦ Synopsis

A dichlorinated alkaloid with a novel skeleton, chingazumianine (1), was isolated from the herb Corydalis koidzumiana, and its structure elucidated by spectroscopic data and X-ray crystallographic analysis. In citratetreated human platelet-rich plasma (PRP), known compounds, i.e., protopine (2), (AE)-tetrahydropalmatine (3), and palmatine (4), isolated from this plant, showed significant inhibition of secondary aggregation induced by adrenaline in a concentration-dependent manner, suggesting that the antiplatelet effects of these compounds is mainly due to an inhibitory effect on thromboxane formation. 13 C-NMR spectra (Table ) showed that 1 had two tetrasubstituted benzene moieties. a ) All assignments were confirmed by 1 H, 1 H COSY, HMQC, HMBC, and NOESY data. b ) Attributions may be reversed.