Chinese Presenilin-1 V97L mutation enhanced Aβ42 levels in SH-SY5Y neuroblastoma cells
✍ Scribed by Boyan Fang; Longfei Jia; Jianping Jia
- Book ID
- 116768871
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 305 KB
- Volume
- 406
- Category
- Article
- ISSN
- 0304-3940
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## Abstract The majority of early‐onset familial Alzheimer disease cases are caused by mutations in the genes encoding presenilin 1 (PS1) and presenilin 2 (PS2). Presenilin mutations have been hypothesised to cause Alzheimer disease either by altering amyloid precursor protein metabolism or by incr
## Abstract Presenilins (PSs) are mutated in a majority of familial Alzheimer disease (FAD) cases. Mutated PSs may cause FAD by a number of pro‐apoptotic mechanisms, or by regulating γ‐secretase activity, a protease involved in β‐amyloid precursor protein processing to the neurotoxic β‐amyloid pept