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Chimeric RNA-DNA oligonucleotide mediated gene correction of a COLI7A1 mutation in keratinocytes of a GABEB patient

โœ Scribed by van der Steege, G.; Nijenhuis, M.; Heeres, K.; Pas, H.H.; Buys, C.H.C.M.; Scheffer, H.; Jonkman, M.F.


Book ID
119562645
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
185 KB
Volume
16
Category
Article
ISSN
0923-1811

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โœ B T Kren; A Cole-Strauss; E B Kmiec; C J Steer ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 597 KB

Although a variety of methods has been devised for modification of hepatic genes, none has been effective for long-term correction of genetic disorders. In this study, we employed a recently described novel experimental strategy for site-directed nucleotide exchange in genomic DNA of HuH-7 human hep