Infection of human hepatocyte chimeric m
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Masataka Tsuge; Nobuhiko Hiraga; Hideki Takaishi; Chiemi Noguchi; Hiromi Oga; Mi
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Article
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2005
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John Wiley and Sons
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English
⚖ 447 KB
Studies of hepatitis B virus (HBV) mutants have been hampered by the lack of a small animal model with long-term infection of cloned HBV. Using a mouse model in which liver cells were highly replaced with human hepatocytes that survived over a long time with mature human hepatocyte function, we perf