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Chimeric MLL products with a Ras binding cytoplasmic protein AF6 involved in t(6;11) (q27;q23) leukemia localize in the nucleus

✍ Scribed by Joh, Tatsuroh; Yamamoto, Kazuhito; Kagami, Yoshitoyo; Kakuda, Harumi; Sato, Takeyuki; Yamamoto, Takaharu; Takahashi, Toshitada; Ueda, Ryuzo; Kaibuchi, Kozo; Seto, Masao

Book ID: 110060921
Publisher: Nature Publishing Group
Year: 1997
Tongue: English
Weight: 702 KB
Volume: 15
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1201332

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Chromosomal analysis of acute monocytic leukemia cells in a female infant revealed a t(6;11)(q27;q23) translocation. Southern blot analysis with a cDNA probe of the MLL gene at chromosome band 11q23 indicated that the breakpoint was in an 8.3-kb BamHI fragment that contained exons 5-11 of the MLL ge