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Chimeric extracellular domain of type II transforming growth factor (TGF)-β receptor fused to the Fc region of human immunoglobulin as a TGF-β antagonist

✍ Scribed by Sylviane Komesli; Denis Vivien; Patrick Dutartre


Book ID
114429191
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
362 KB
Volume
254
Category
Article
ISSN
1432-1327

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Expression of Recombinant Extracellular
✍ Mark S. Fahey; David Dawbarn; Shelley J. Allen; Ian C. Paterson; Stephen S. Prim 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 87 KB

TGF-␤ is a ubiquitous protein that exhibits a broad spectrum of biological activity. The prokaryotic expression and purification of the extracellular domain of the type II TGF-␤ receptor (T␤R-II-ED), without the need for fusion protein cleavage and refolding, is described. The recombinant T␤R-II-ED