Children's health risk assessment: incorporating a lifestage approach into the risk assessment process

✍ Scribed by Rebecca C. Brown; Stanley Barone Jr.; Carole A. Kimmel

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 212 KB
• Volume: 83
• Category: Article
• ISSN: 1542-9733
• DOI: 10.1002/bdrb.20172

✦ Synopsis

Abstract

This overview paper provides the historical context for the incorporation of lifestage‐specific concerns in human health risk assessment, briefly explains the process employed in a lifestage framework for risk assessment, and discusses the scientific rationale for how utilizing lifestage data will strengthen the overall risk assessment process. This risk assessment approach will add value by: (1) providing a more complete evaluation of the potential for vulnerability at different lifestages, including a focus on the underlying biological events and incorporation of mode of action information related to different critical developmental periods; (2) evaluating the potential for toxicity during all lifestages after early lifestage exposure; (3) reviewing the importance of integrating exposure information and adverse health effects across lifestages; and (4) serving as a basis to extend some aspects of the children's health risk assessment framework to all lifestages. Birth Defects Res (Part B), 2008. © 2008 Wiley‐Liss, Inc.