Childhood stage IV Hodgkin disease: Therapeutic results of the Polish Pediatric Leukemia/Lymphoma Study Group
✍ Scribed by Armata, Jerzy; Balwierz, Walentyna; Moryl-Bujakowska, Angelina; Bogus?awska-Jaworska, Janina; Pisarek, Jolanta; So�ta-Jakimczyk, Danuta; Janik-Moszant, Anna; Rokicka-Milewska, Roma; Sopy?o, Barbara; Ko?akowska-Mrozowska, Beatrycze; Ko?ecki, Pawe?; Kaczmarek-Kanold, Ma?gorzata; Kowalczyk, Jerzy; Skomra, Stanis?aw; Matysiak, Micha?; Newecka-Sam�l, Teresa
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 77 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Background. The therapeutic management in patients with stage IV Hodgkin disease is still controversial. Procedure. Among 783 children with Hodgkin disease treated from 1971 to 1996, 56 patients (7.3%) were diagnosed with stage IV. The treatment consisted of MVPP or MVPP/B-DOPA chemotherapy combined with involved-field radiotherapy in 50 children. Results. The results of treatment of stage IV pa- tients were compared in the three sequential time periods, during which the therapy was modified. In these periods, the first complete remission was obtained in 67%, 86%, and 90% of children, respectively, and the 10-year event-free survival was 42%, 64%, and 85%, respectively. Conclusions. Alternate multidrug chemotherapy combined with low-dose involved-field radiotherapy is at present a satisfactory therapeutic method in children with stage IV Hodgkin disease.