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Childhood Adversity Increases Risk for Nicotine Dependence and Interacts with α5 Nicotinic Acetylcholine Receptor Genotype Specifically in Males

✍ Scribed by Xie, Pingxing; Kranzler, Henry R; Zhang, Huiping; Oslin, David; Anton, Raymond F; Farrer, Lindsay A; Gelernter, Joel


Book ID
121676195
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
355 KB
Volume
37
Category
Article
ISSN
1470-634X

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## Abstract Nicotinic acetylcholine receptors bind to nicotine and initiate the physiological and pharmacological responses to tobacco smoking. In this report, we studied the association of α5 and α3 subunits with nicotine dependence and with the symptoms of alcohol and cannabis abuse and dependenc